Noninvasive Assessment of Cerebral Oxygenation and Cardiac Function in Patients With Neurovascular Diseases

National Institute of Mental Health and Neuro Sciences, India25 enrolled

Overview

This prospective observational study will assess the regional cerebral oxygen saturation and cardiac output non-invasively in patients with subarachnoid hemorrhage during nimodipine administration for the prevention/management of cerebral vasospasm.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Subarachnoid Hemorrhage, Aneurysmal

Interventions

NimodipineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aneurysmal subarachnoid hemorrhage * potential or actual cerebral vasospasm Exclusion Criteria: * non-aneurysmal subarachnoid hemorrhage * outside the 4-21 day window after ictus * peripheral deoxygenation * contraindication for nimodipine administration

Locations (1)

NIMHANS

Bengaluru, India

Outcomes

Primary Outcomes

Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine

Time frame: Change from baseline cerebral oxygen saturation at 30 minutes after administration of nimodipine

Secondary Outcomes

Change in the cardiac output measured using near NICOM technology after administration of nimodipine

unit of measurement will be L/min

Time frame: Change from baseline cardiac output at 30 and 240 minutes after administration of nimodipine

Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine

Time frame: Change from baseline cerebral oxygen saturation at 240 minutes after administration of nimodipine

Data from ClinicalTrials.gov

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