Contrast media-induced nephropathy following diagnostic and therapeutic cardiac catheterization.
Contrast-induced acute kidney injury represents a serious complication of procedures requiring administration of iodinated contrast media and is associated with the need for dialysis, prolonged hospitalization, increased costs, and mortality. Contrast-induced nephropathy is defined as an increase of 25% in serum creatinine before the procedure. Iodixanol, a nonionic, dimeric, iso-osmolar contrast medium may be less nephrotoxic than low-osmolar contrast media in high-risk patients. The purpose of this study is to compare iodixanol versus ioxaglate in high risk patients between 48 and 96 hours after procedures that use contrast.
Study Type
OBSERVATIONAL
Enrollment
2,262
Compare 2 contrast media
Contrast-induced nephropathy incidence
Time frame: Between 48 and 96 hours after diagnostic and therapeutic cardiac catheterization
Composite of death or need for dialysis in 48 to 96 hours and at 30 days after diagnostic and therapeutic cardiac catheterization
Need for dialysis when patient develop end stage kidney failure -- by the time patient lose about 85 to 90 percent of your kidney function and have a glomerular filtration rate of \<15.
Time frame: 30 days
The individual components of the combined outcome (total mortality or dialysis indication)
Time frame: 30 days
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