With the potential to address evaporative dry eye, Liposic and Tears Naturale Forte have been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. This study compare the effects of Liposic and Tears Naturale Forte application on the lipid and stability of the tear film in dry eye patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
one eye of the participant recieved Lipoic
the other eye of the participant recieved Tears Naturale Forte
Hainan Eye Hospital, Zhongshan Ophthalmic Center of Sun Yat-sen University
Haikou, Hainan, China
RECRUITINGscale of Schirmer I test
Time frame: up to 3 months after tear substitutes apply
scale of corneal fluorescein staining
Time frame: up to 3 months after tear substitutes apply
scale of noninvasive tear breakup time
Time frame: up to 3 months after tear substitutes apply
scale of tear meniscus height
Time frame: up to 3 months after tear substitutes apply
lipid layer grade
Time frame: up to 3 months after tear substitutes apply
questionnaire of ocular surface disease index
Time frame: up to 3 months after tear substitutes apply
subjective comfort
Subjective comfort was established at each time-point by asking subjects, firstly, to relate their comfort to baseline in each eye (more comfortable/no different/less comfortable) . secondly, to express a preference for their more comfortable eye (right eye/left eye/no difference)
Time frame: up to 3 months after tear substitutes apply
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