Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes

Han Yuan300 enrolled

Overview

To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Postoperative Cognitive Dysfunction

Eligibility

Sex: ALLMin age: 60 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * Between 60 to 85 years old; * Undergoing non-cardiac and non-neurological surgery under general anesthesia; * Expected hospital stay ≥5 days; * American Society of Anesthesiologists class I or II. Exclusion criteria: * Mental or neurodegenerative diseases; * History of severe trauma or surgery within one year; * History of nasal or sinus illness or surgery; * Cold or influenza within 3 weeks; * Significant history of organ dysfunction; * Previous neuropsychological testing; * Difficulty to perform tests (including severe visual or auditory disorders); * Mini-Mental State Examination (MMSE) \<24 points, \<20 points if the participant only attended elementary school, or \<17 points if the participant did not go to school.

Locations (1)

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

Outcomes

Primary Outcomes

the neuropsychological test battery to measure cognitive function

Time frame: 1 day before surgery(baseline)

olfaction test to measure the sense of smell

Time frame: 1 day before surgery(baseline)

the neuropsychological tests to measure cognitive function

Time frame: within 5 to 10 days (average of 7 days) after surgery

olfaction test to measure the sense of smell

Time frame: within 5 to 10 days (average of 7 days) after surgery

Data from ClinicalTrials.gov

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