The Efficacy of Butylphthalide Soft Capsules in Patents With VCIND

Inclusion Criteria: * Literate Han Chinese aged from 40 to 65 years * MMSE ≥24 * Normal or slightly impaired activities of daily living * The MRI entry criteria are as follows: * Subcortical small infarcts (3-20 mm in diameter),or one or more strategically located subcortical small infarcts in the caudate nucleus globus pallidus, or thalamus * Absence of cortical and watershed infarcts, hemorrhages, hydrocephalus, and WMLs with specific causes (e.g., multiple sclerosis); and * No hippocampal or entorhinal cortex atrophy (scored 0 according to medial temporal lobe atrophy scale of Scheltens) Exclusion Criteria: * Patients with Diabetes mellitus * Disorders other than subcortical VCIND that may affect cognition; the score of Hamilton depression scale more than 17 or schizophrenia * Clinically significant gastrointestinal, renal, hepatic, respiratory, infectious, endocrine, or cardiovascular system disease; cancer; alcoholism; drug addiction; use of medications that may affect cognitive functioning * Known hypersensitivity to celery * Inability to undergo a brain MRI