DASH-Sodium Trial in Adolescents

Purdue University79 enrolled

Overview

The Camp DASH study trial will compare the effect of two dietary patterns and two levels of sodium intake on blood pressure and blood lipids in adolescents in the upper third of distribution for blood pressure. The two dietary patterns are based on the Dietary Approaches to Stop Hypertension (DASH) trial in adults.

The Camp DASH study is a controlled trial. the aim of which is to compare the effect of two dietary patterns and two levels of sodium intake on blood pressure and blood lipids in adolescents in the upper third of distribution for blood pressure. The study also assesses whether influences on blood pressure and blood lipids of dietary interventions vary according to sex, race/ethnic groups, baseline levels, and other personal characteristics. The proposed dietary interventions of DASH dietary patterns and sodium reduction have been shown to be effective in lowering blood pressure in adults. The two dietary patterns are based on the Dietary Approaches to Stop Hypertension (DASH) trial in adults. They are a Usual diet typical of what many American adolescents eat, and a DASH-type diet. The DASH diet is rich in fruits, vegetables, and low-fat dairy foods and low in saturated fat and total fat compared to the Usual diet. The two sodium levels are High reflecting current US consumption and Low reflecting current recommended intake levels. Weight will be held constant by adjusting energy intake. The study participants will live in a residence hall on the Purdue campus where all food and beverages will be provided, and meals and snacks will be supervised.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Blood High Pressure

Interventions

DASH dietOTHER

DASH style diet rich in fruits, vegetables, and low-fat dairy foods and low in saturated fat and total fat

Low Na dietOTHER

Sodium intake of 1500 mg/d (65 mmol, or 0.75 mg/Kcal/d), representing the Adequate Intake recommended by the Institute of Medicine.

High Na dietOTHER

Sodium intake of 3500 mg/d (152 mmol, or 1.73 mg/Kcal/d, representing the highest sodium intake used for adults in the DASH Sodium trial.

Eligibility

Sex: ALLMin age: 11 YearsMax age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * White, black, Hispanic, and Asian * SBP in the upper one-third of the distribution for their given sex, age, and height Exclusion Criteria: * Pre-existing lipid disorders, abnormal liver or kidney function * Taking medications that alter mineral absorption or metabolism, affect blood pressure or lipids * If subjects are taking dietary supplements and refuse to discontinue them 2 months prior to the study. * Taking non-prescription illegal drugs, smoke, or drink alcohol * Pregnancy * Carry an epi pen for food-related allergies

Locations (2)

Department of Pediatrics, IU School of Medicine

Indianapolis, Indiana, United States

Department of Nutrition Science, Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

Mean systolic blood pressure (SBP)

The primary outcome is mean SBP at the end of each intervention feeding period. Mean end of intervention SBP is the average of daily readings during days 19-25 of each intervention feeding period. Blood pressure will also be measured periodically at baseline and throughout the study.