Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy

Ege University85 enrolled

Overview

Patients who have doubt for ectopic pregnancy will be enrolled for our study. These patients will be determined with using irregular increased human chorionic gonadotropin (beta-HCG) results and no embryo reported ultrasonography results. Plasma and cervical fluid samples will be taken from these patients and axonemal dynein heavy chain 5 and creatine kinase levels of samples will be compared between patients who have doubt for ectopic pregnancy and patients who have intrauterine pregnancy. Concentration of these proteins in samples will be evaluated. If any difference will be found between groups in favour of ectopic pregnancy, these results might be interpreted as these proteins useful for early detecting of the ectopic pregnancy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ectopic Pregnancy

Interventions

Collecting cervical liquid and sera samplesOTHER

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Doubted ectopic pregnancy * Without any finding about intrauterine pregnancy in ultrasonography results * Without any vaginal bleeding * Having irregular pregnancy test results * Beta-HCG results should be at least upper than 100 milli-International unit (mIU/ml) * Having fist trimester pregnancy for intrauterine pregnancy group * Without any emergency findings Exclusion Criteria: * Doubted incomplete abortion * Having vaginal bleeding * Having ultrasound results which include intrauterine embryo report * Having lower than 100 mIU/ml beta-HCG results * Without fetal heart rate in intrauterine pregnancy group * Having older than fist trimester pregnancy for intrauterine pregnancy group * Having emergency findings

Outcomes

Primary Outcomes

Concentration of Axonemal Dynein Heavy Chain 5

Time frame: 1 year

Concentration of creatine kinase