Endoscopic Lung Volume Reduction Coil Treatment in Patients With Chronic Hypercapnic Respiratory Failure

Universitätsklinikum Hamburg-Eppendorf1 enrolled

Overview

Endoscopic lung volume reduction coil treatment is a treatment option for selected patients with severe emphysema. In the advanced stages, emphysema may lead to chronic hypercapnic respiratory failure. In this observational study the safety and efficacy of endoscopic lung volume reduction coil treatment in patients with chronic hypercapnic respiratory failure is evaluated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Emphysema

Interventions

Endoscopic lung volume reduction coil treatmentPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with emphysema (chronic obstructive pulmonary disease with forced expired volume in one second (FEV1) \< 50% predicted and residual volume (RV) ≥ 200% predicted) in whom endoscopic lung volume reduction coil treatment is performed * Chronic hypercapnic respiratory failure (PaCO2 ≥ 50 mmHg) * Informed consent Exclusion Criteria: * Therapeutic anticoagulation * Anti-platelet therapy exceeding the use of acetylsalicylic acid * Severe pulmonary hypertension

Locations (1)

University Hospital Hamburg-Eppendorf

Hamburg, Germany

Outcomes

Primary Outcomes

Changes in PaCO2

Time frame: 3 months after endoscopic lung volume reduction (ELVR)