Paclitaxel Liposome for Squamous Non-Small-cell Lung Cancer Study(LIPUSU)

Inclusion Criteria: 1. Aged 18-75 years old, both gender; 2. ECOG: 0-1; 3. Squamous non-small-cell lung cancer (stage IIIB or IV) confirmed by histologically or cytologically ; 4. No prior chemotherapy, biological therapy or immunotherapy; or subjects have recurrence and metastasis more than 6 months after the end of chemotherapy, but not gemcitabine or paclitaxel; 5. At least one radiographically measurable or assessable lesion on chest CG according to RECIST1.1 (response evaluation criteria of solid tumors); regional lymph node metastases may also be measured or assessed by imaging (mediastinal lymph nodes); 6. Life expectancy of at least 12 weeks; 7. Before treatment, blood tests or biochemical measurements must meet the following criteria: * White blood cell count (WBC)≥ 4.0\*10\^9/L; * Neutrophil count (ANC)≥ 2.0\*10\^9/L; * Platelet count (PLT)≥ 100\*10\^9/L; * Hemoglobin (Hb)≥ 100g/L; * Hepatic function: serum bilirubin ≤ 1.5 times the upper normal limit,aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 times the upper normal limit; * Renal function: creatinine ≤ 1.5 times the upper normal limit; 8. Signed informed consent. Exclusion Criteria: 1. Hypersensitivity reaction to the interventional drugs; 2. Pregnant or breastfeeding; 3. Women or men of childbearing age who disagree with the use of effective contraceptive measures during the study period; 4. Brain metastase ; 5. Uncontrolled pleural effusion in patients with squamous non-small-cell lung cancer