Chorioamnionitis and Proinflammatory S100A12

Catholic University of the Sacred Heart69 enrolled

Overview

Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS) and increased levels of proinflammatory molecules.

Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS). The aim of this pilot study was to evaluate S100A12, a marker of innate immune activation, in mothers with or without HCA and in their infants. Concentrations of S100A12, Interleukin 6 (IL-6) and C-reactive protein (CRP) were evaluated in maternal, cord, and neonatal blood of very preterm infants. Histologic examinations of placentae and umbilical cords were performed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chorioamnionitis Affecting Fetus or Newborn

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: Preterm Birth Exclusion Criteria: Congenital Abnormalities

Outcomes

Primary Outcomes

S100A12 in Presence of Maternal Chorioamnionitis

Levels of S100A12 in Maternal, Cord and Neonatal Blood in the Presence or Absence of HCA

Time frame: 1 Year

Data from ClinicalTrials.gov

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