Zika-Vaccine Dose Finding Study Regarding Safety, Immunogenicity and Tolerability (V186-001)

Inclusion Criteria: * healthy volunteers aged 18 to 55 * subjects of child bearing potential must perform reliable method of contraception Exclusion Criteria: * immune deficiency, history of HIV, HBV, HCV * drug addiction * vaccination within 4 weeks prior to study or planned vaccination during study * prior receipt of any Zika vaccine * recent infection 1 week prior to screening * relevant medical history interfering with aim of study * neoplastic disease, hematological malignancy * history of autoimmune disease * psychological condition that affects ability to participate in the study * history of severe adverse reactions to vaccine administration * history of anaphylaxis * allergic reactions, abnormal lab values, or concomitant medication per decision of the investigator * use of immunosuppressive drugs within 30 days before screening or planned use during study * receipt of blood products within 120 days before screening or planned use during study * pregnancy, unreliable contraception method * decision of the investigator * regular blood plasma donor