Treatment of Steroid Dependent Idiopathic Nephrotic Syndrome in Children With Low Doses of Interleukin 2: a Pilot Study

Inclusion Criteria: * Children between 3 and 15 years of age (included) with a steroid responsive idiopathic nephrotic syndrome * Idiopathic nephrotic syndrome progressing for less than 1 year * Steroid dependent idiopathic nephrotic syndrome (at least 1 relapse when steroids are tapered off or within 3 months after their withdrawal, and reliance on steroids \> 15 mg/m² every other day) * Steroid dose at inclusion between 15 and 60 mg/m²every other day * Patient with a stable dose of steroids within the 8 days before and after the first injection of IL2 * Patient in remission for more than 15 days * Patient affiliated to a French health insurance * Signed consent of parental authority Exclusion Criteria: * Hypersensitivity to IL2 or to one of its excipients * Significant history or presence of cardiopathy * Signs of evolving infection requiring an antibiotic treatment * Respiratory distress, respiratory infection or chronic respiratory failure * Serious dysfunction of one of the vital organs * Leukocytes \< 4000/mm3 ; platelets \< 100 000/mm3; hematocrit \<30% * Anomaly of serum bilirubin and creatinin levels * History of organ allograft * Other pre-existing autoimmune disease * Male and female pubescent teenagers under the age of 15 * Male and female teenagers whose puberty has begun for more than one year * Asthmatic patient * Pregnant or breastfeeding female patient * Participation in another therapeutic trial concurrently or 30 days prior to inclusion