Rupture of abdominal aortic aneurysms(AAA) causes 12,000 deaths/year in the UK.1 Elective repair to prevent this carries a perioperative mortality of 4.5% for open surgery and 1% for endovascular repair. This risk is associated with poor cardiorespiratory fitness which can be measured using Cardiopulmonary Exercise Testing(CPET) with the CPET variables, peak oxygen uptake(peakVO2)\<15ml/kg/min and anaerobic threshold(AT)\<10.2ml/kg/min identifying patients at increased risk of early death after AAA repair.3 These variables can therefore be used as surrogate markers for cardiovascular fitness and risk of mortality and morbidity in AAA surgery; optimising these markers should improve fitness and decrease this risk. The optimal duration and type of exercise training for improving peak VO2 and AT in AAA patients is not known. AAA patients are unique as they are motivated to reduce the risk of impending surgery but are afforded the time to improve their fitness as repair may not be needed for months or even years. The investigators propose a pilot randomised controlled trial to explore the effectiveness of a 20-week community (either home or gym-based) exercise programme to achieve sustained improvements in peak VO2 and AT, as measured by CPET, in AAA patients. Changes in QoL, habitual activity levels and cardiovascular risk will also be assessed. The results will inform a definitive multicentre clinical trial on exercise to improve outcomes in elderly patients with cardiovascular disease and AAA.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
58
20 week community (home or gym based) exercise programme
Usual care consisting of advice.
Peak VO2 as measured by CPET
Time frame: at 20 weeks
Anaerobic Threshold as measured by CPET
Time frame: at 20 weeks
Biomarkers of Cardiovascular disease risk
Time frame: at 20 weeks
Other risk factors of Cardiovascular disease risk
Weight, BMI, Waist Circumference and Blood Pressure
Time frame: at 20 weeks
Subjective measure of habitual activity levels (PASE questionnaire)
Time frame: at 20 weeks
Objective measure of habitual activity levels (via Accelerometry)
Time frame: at 20 weeks
Health-related quality of life
Time frame: at 20 weeks
Early changes in outcome measures
All outcome measures will also be measured at 10 weeks and compared with other time intervals.
Time frame: at 10 weeks
Sustainability of changes in outcome measures
All outcome measures recorded 10 weeks post cessation of exercise at 30 weeks and compared with the other time intervals.
Time frame: at 30 weeks
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