The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.
In this protocol, subjects who are anticipated to be operated for hip fracture will be studied after surgery. Brief cognitive exam will be done followed by fMRI of connectivity and diffusion tensor imaging (DTI). Connectivity (neuronal changes) and DTI (Anisotropy and mean diffusivity) data will be compared with age matched controls and correlated with subjective measures of cognition.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
2
fMRI for measuring function connectivity and DTI will be done between day 2 to day 5.
A measure of general cognition
A measure of current cognition using digital pen technology
UF Health
Gainesville, Florida, United States
Changes between baseline and follow up visits as assessed by fMRI
fMRI for measuring function connectivity and DTI
Time frame: Change from baseline up to 90 days
Changes between baseline and follow up visits as assessed by MoCA
A measure of general cognition
Time frame: Change from baseline up to 90 days
Changes between baseline and follow up visits as assessed by Digital Clock Drawing Test Command and Copy
a measure of current cognition using digital pen technology
Time frame: Change from baseline up to 90 days
Changes between baseline and follow up visits as assessed by Wide Range Achievement Test reading subtest
A measure of premorbid intellectual estimate
Time frame: Change from baseline up to 90 days
Changes between baseline and follow up visits as assessed by HVLT
A measure of declarative memory
Time frame: Change from baseline up to 90 days
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A measure of premorbid intellectual estimate
A measure of declarative memory
A measure of the of presence of depression.