Assess the impact of chronic use of aspartame on glycemia, appetite and body composition.
Participants will be randomly assigned to one of three parallel arms: 0% (water), 5 mg, 15mg aspartame. Participants will have an oral glucose tolerance test at the beginning and end of a 12 week intervention. . Participants will report to the lab weekly for 12 weeks to pick up their next week's intervention products and measurements for body weight, waist circumference, blood pressure and heart rate. They will consume their intervention products daily for 12 weeks. They will record appetite sensations and collect a 24 hour urine sample at weeks 0, 4, 8, and 12.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
93
Purdue Univeristy
West Lafayette, Indiana, United States
change oral glucose tolerance
sample taken at time point 0
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 15 minutes post glucola
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 30 minutes post glucola
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 60 minutes post glucola
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 90 minutes post glucola
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 120 minutes post glucola
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 180 minutes post glucola
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 240 minutes post glucola
Time frame: week 0 4 hours
change oral glucose tolerance
sample taken at time point 0
Time frame: week 12 4 hours
change oral glucose tolerance
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
sample taken at time point 15 minutes post glucola
Time frame: week 12 4 hours
change oral glucose tolerance
sample taken at time point 30 minutes post glucola
Time frame: week 12 4 hours
change oral glucose tolerance
sample taken at time point 60 minutes post glucola
Time frame: week 12 4 hours
change oral glucose tolerance
sample taken at time point 90 minutes post glucola
Time frame: week 12 4 hours
change oral glucose tolerance
sample taken at time point 120 minutes post glucola
Time frame: week 12 4 hours
change oral glucose tolerance
sample taken at time point 180 minutes post glucola
Time frame: week 12 4 hours
change oral glucose tolerance
sample taken at time point 240 minutes post glucola
Time frame: week 12 4 hours
Appetite
questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly for one day.
Time frame: every hour for 1 day at week 0
Appetite
questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly for one day
Time frame: every hour for 1 day at week 4
Appetite
questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly for one day
Time frame: every hour for 1 day at week 8
Appetite
questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly for one day
Time frame: every hour for 1 day at week 12
Body composition
body composition measurement Plysmography (BOD POD)
Time frame: week 0
Body composition
body composition measurement Plysmography (BOD POD)
Time frame: week 12