Focusing on newly diagnosed type 2 diabetes participants with overweight and obesity (24kg/m2 ≤ body mass index ≤ 30kg/m2). 50 participants per arm (acarbose \& lifestyle combination / vildagliptin \& lifestyle combination), using abdominal computed tomography scans and other methods to evaluate the effects of acarbose and vildagliptin on visceral fat distribution in overweight and obesity patients with newly diagnosed type 2 diabetes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
1-2 week: 50mg tid; 3-24 week: 100mg tid.
1-24 week: 50mg bid
Beijing Pinggu Hospital
Beijing, Beijing Municipality, China
RECRUITINGChange of the visceral fat area in square centimeter assessed by abdominal CT scans from baseline to 24 weeks.
Time frame: 24 weeks
Change of body weight in kilograms measured by investigators from baseline to 24 weeks.
Time frame: 24 weeks
Change of waist circumstance in centimeters measured by investigators from baseline to 24 weeks.
Time frame: 24 weeks
Change of body mass index in kg/m^2 measured by investigators from baseline to 24 weeks.
Time frame: 24 weeks
Change of the subcutaneous fat area in square centimeters assessed by abdominal CT scans from baseline to 24 weeks.
Time frame: 24 weeks
Change of hemoglobin A1c in percents from baseline to 24 weeks.
Time frame: 24 weeks
Change of hemoglobin fasting plasma glucose in millimols per liter from baseline to 24 weeks.
Time frame: 24 weeks
Change of hemoglobin 2-hour-post-prandial plasma glucose in millimols per liter from baseline to 24 weeks.
Time frame: 24 weeks
Change of triglyceride in millimols per liter from baseline to 24 weeks.
Time frame: 24 weeks
Change of total cholesterol in millimols per liter from baseline to 24 weeks.
Time frame: 24 weeks
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Change of low-density lipoprotein-cholesterol in millimols per liter from baseline to 24 weeks.
Time frame: 24 weeks
Change of high-density lipoprotein-cholesterol in millimols per liter from baseline to 24 weeks.
Time frame: 24 weeks
Change of insulin in international units per liter from baseline to 24 weeks.
Time frame: 24 weeks
Change of brain natriuretic peptide in nanograms per milliliter from baseline to 24 weeks.
Time frame: 24 weeks