High-Intensity Interval Training on Pre-Hypertensive Subjects

Universidad Santo Tomas142 enrolled

Overview

Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

142

Conditions

Metabolism Disorder Hypertension

Interventions

High Intensity Interval TrainingBEHAVIORAL

High Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.

Control groupBEHAVIORAL

Moderade Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent; * Interested in improving health and fitness; * Systolic blood pressure \> 120 mmHg and \< 140 mmHg, and/or DBP ≥ 80 and \< 90 mmHg according with standard classification; * No drug therapy during the previous 3 months; * Body mass index (BMI) 25 and 35 kg/m2); (c) physically inactive (according to the International Physical Activity Questionnaire previously validated in Chilean population) * Normal /mild altered lipid profile (total cholesterol \[TC\] \~200 and ≤250 mg/dL, low-density lipids \[LDL-C\] \~140 mg/dL and ≤200 mg/dL, high-density lipids \[HDL-C\] ≥20 and \~40 mg/dL, triglycerides \~150 and ≤250 mg/dL) according with standard classification. Exclusion Criteria: * Cardiovascular contraindications to exercise histories of stroke; * Asthma and chronic obstructive pulmonary disease; * Musculoskeletal disorder such as low back pain; * Smokers in the last 3 months were not included in the study.

Locations (1)

Cristian Alvarez

Osorno, Chile

Outcomes

Primary Outcomes

Change from Baseline in systolic blood pressure and diastolic blood pressure

After this, we calculated the delta changes in both variables and classified to all subjects in responders (R) and non-responders (NR) to decrease systolic or diastolic blood pressure.