A Trial of a Botanical Drug Product Containing East Indian Sandalwood Oil (EISO) For Treatment of Atopic Dermatitis

Inclusion Criteria: 1. Are at least 3 months of age 2. Have atopic dermatitis, as determined by an EASI score of ≥5 and ≤50 (Hanifin, 2001) 3. Total treatment area(s) of atopic dermatitis involvement ≥2% and ≤10% body surface area (BSA). 4. Have atopic dermatitis that has been clinically stable for ≥ 1 month prior to the Screening Visit. 5. Are able to obtain written informed consent/ascent in a manner approved by the Institutional Review Board and comply with the requirements of the study. 6. Are willing to refrain from using any lotions, moisturizer, cleansers, cosmetics or creams, other than those issued as part of the study, on the target treatment areas during the treatment period. 7. Are free of any systemic or dermatologic disorder, which, in the opinion of the investigator, will interfere with the study results or increase the risk of adverse events. 8. Are willing to refrain from exposure to artificial ultraviolet radiation for the duration of the study. 9. Are willing to cover target treatment areas to avoid exposure to natural ultraviolet radiation for the duration of the study. 10. If female of childbearing potential, must be willing to practice an acceptable form of birth control for the duration of the study. i.e. barrier method, hormone or intrauterine device. 11. Are willing to avoid participation in any other clinical trial for the duration of this study. 12. Are willing to refrain from treating areas that are not the defined treatment area(s), which will be excluded from all assessments and BSA calculation. 13. Are willing to refrain from treating study restricted areas. Study restricted areas are as follows: head, neck, soles of feet, palms of hands, axillae, or intertriginous areas. Exclusion Criteria: 1. Have a sibling or immediate family member already participating in this trial. 2. Currently requires and/or, in the past month, has required topical use of a medium or high potency steroid. 3. Atopic dermatitis that, in the opinion of the investigator, is likely to stem from an allergic reaction. (i.e. contact dermatitis) 4. Have \<2% of atopic dermatitis involvement eligible for treatment. 5. Have participated in any interventional clinical trial in the previous 30 days to the screening visit. 6. Have a known sensitivity to any of the constituents of the test product including sensitivities to sandalwood oil, fragrances or any member of the Compositae family of vascular plants (e.g., sunflowers, daisies, dahlias, etc.). 7. Have received phototherapy within the last 2 months prior to enrollment. 8. Have received any systemic medication for atopic dermatitis in the past 2 months that would interfere with the evaluation of atopic dermatitis (excluding antihistamines or leukotriene inhibitors). 9. Have a present condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. 10. Are pregnant, breast-feeding or plan to become pregnant at any point for the duration of the trial. 11. Are not willing to practice an approved form of birth control while on the study drug for the duration of the trial. i.e. barrier method, hormone or intrauterine device. 12. Have been treated, with prescription medication for atopic dermatitis, with no improvement in condition, within 60 days prior to the Baseline visit. 13. Have any evidence of systemic cancer, squamous cell carcinoma, basal cell carcinoma, or any other confounding skin condition. 14. Have undergone treatments with topical atopic dermatitis drug products, other than retinoids or corticosteroids, within 14 days prior to the Baseline Visit, and for therapy containing corticosteroids or retinoids within 28 days prior to Baseline Visit. 15. Have open sores or open lesions in the treatment area(s). 16. Have a history of alcohol or illegal drug/substance abuse, or suspected alcohol or illegal drug/substance abuse in the past two years. 17. Require greater than 2.0 mg/day inhaled or intranasal corticosteroids. 18. Have an active infection of any kind at Baseline 19. Have an occupation that requires ≥50% of time be spent outdoors, where prolonged exposure to ultraviolet radiation is unavoidable.