Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients.

Inclusion Criteria: 1. Patients must consent in writing to participate in the study by signing and dating an informed consent document 2. Patients who can communicate (exclusion of anyone who cannot understand the questionnaire) 3. between 20 years and 80 years of age 4. BMI≤30 5. Diagnosis of osteoarthritis by radiographic criteria of Kellgren and Lawrence grade 2-4 6. Diagnosis of osteoarthritis by ACR(American College of Rheumatology Criteria) Global functional criteria : There is the pain of the knee and radiographic osteophyte and at least one of the following (1) age \>50 years (2) Less than 30 minutes of morning stiffness (3) The friction When moving weighted the knee 7. Patients who agree with contraception 8. Patients who agree to stop the existing osteoarthritis treatment and to get enough washout periods until medication time 9. Patients scheduled for High tibial osteotomy due to medial gonarthrosis Exclusion Criteria: 1. patients with osteoporosis 2. Preparing for Pregnancy or Pregnant women or lactating mothers. 3. Patients with positive human immunodeficiency (HIV), hepatitis B (HBV), hepatitis C (HCV), venereal disease research laboratory(VDRL) 4. Patients with hypersensitivity to investigator product or investigational product component or those with a history 5. Patients who had participated in other clinical trials within 12 weeks prior to this study 6. Patients who received any drug by intra-articular injection for treatment within 2 months prior to this enrollment. 7. Patients who experienced as the knee joint cartilage and stem cell therapy or failure to treat 8. Patents who started or changed the physical therapy program established within 2 weeks before the start of the study or during the study(An established physical therapy program may continue for the duration of the trial, provided that it does not change in frequency and intensity) 9. Patents included in the following specific risk groups that may influence safety and efficacy assessments at the discretion of the investigator:: septic arthtritis, rheumatic disease, gout, recurrent pseudogout, paget disease, joint fracture, alcaptonuria, acromegaly, hemochromatosis, wilson's disease, primary osteochondrosis, hereditary disorder(ex: hyperkinesia), collagen gene abnormality ,etc 10. Patients who have clinically significant severe medical illnesses judged the principal investigator 11. Patients who have been diagnosed with malignancy within 5 years before screening (except for patients who were completely remissioned three years before screening criteria) 12. Patients who the principal investigator consider inappropriate for the clinical trial due to any other reasons 13. Patients who received concomitant contraindications and who have not passed the prescribed wash-out period before participating in the clinical trial