Prevention of Postoperative Pancreatic Fistula by Somatostatin

Inclusion Criteria: * Men or women aged 18 years or greater * Signed informed consent * Candidate for pancreaticoduodenectomy or distal pancreatectomy with or without splenectomy Exclusion Criteria: * Patient with radiation therapy * Patient with neoadjuvant chemotherapy within 4 weeks before surgery * Pregnancy * Breastfeeding * Patients who have any current or prior medical condition that may interfere with the conduct of the study or the evaluation of its results in the opinion of the Investigator * Patients who have participated in any clinical investigation with an investigational drug within 1 month prior to inclusion * Known hypersensitivity to somatostatin or somatostatin analogues or any component of the somatostatin or octreotide long-acting release (LAR) or s.c. formulations * Patient previously treated with somatostatin or somatostatin analogues or any component of the somatostatin or octreotide LAR or s.c. formulations * Patients treated by ciclosporin * Patient without health insurance or social security * Patients with a history of non-compliance to medical regimens or who are considered potentially unreliable or will be unable to complete the entire study