Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects

Early Phase 1UnknownNCT03001271

Instituto de Cardiologia do Rio Grande do Sul32 enrolled

Overview

In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Hypertension

Interventions

Angiotensin 1-7DRUG

PlaceboOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Healthy Group Inclusion Criteria: * arterial pressure \<140/90 mmHg * body mass index (BMI) between 18,5 and 29 Kg/m2 Hypertensive Group Inclusion Criteria: * anti-hypertensive drug treatment * ambulatory blood pressure monitoring (ABMP) \>130/85 mmHg * body mass index between 18,5 and 29 Kg/m2 Healthy Group Exclusion Criteria: * drug treatment * recent surgeries * pregnancy * previous cardiovascular events * high performance athletes * dislipidemia * diabetes * renal injury * obesity (BMI above 30 kg/m2) * alcoholism * smoking. Hypertensive Group Exclusion Criteria: * recent surgeries * pregnancy * beta-blockers drug treatment * previous cardiovascular events * high performance athletes * dislipidemia * diabetes * renal injury * obesity (BMI above 30 kg/m2) * alcoholism * smoking

Outcomes

Primary Outcomes

Absence of adverse effects after Ang-(1-7) acute administration

Time frame: Along 25 hours

Secondary Outcomes

Blood Pressure Changes after Ang-(1-7) administration

absence of measure changes in blood pressure or heart rate (increase or decrease)

Time frame: Recording along 24 hours

Ang-(1-7) effects on Blood Pressure Variability

Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration

Time frame: Along 1 hours after Ang-(1-7) acute administration

Heart Rate Changes after Ang-(1-7) administration

Time frame: Recording along 24 hours

Ang-(1-7) effects on Heart Rate Variability

Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration

Time frame: Along 1 hours after Ang-(1-7) acute administration

Data from ClinicalTrials.gov

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