Thyroid Function and Diabetes Complications

Nanjing First Hospital, Nanjing Medical University260 enrolled

Overview

The purpose of this study is to investigate the potential association between thyroid function and diabetes complications in the elderly subjects with type 2 diabetes mellitus (T2DM).

Aims: We investigated the potential association between thyroid parameters and microalbuminuria in the euthyroid elderly subjects with type 2 diabetes mellitus (T2DM). Subjects: Elderly inhospital patients with T2DM who visited in the Department of Endocrinology at the Nanjing First Hospital from January 2011 to December 2012. Methods: Clinical factors, serum levels of glucose, lipids, free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid autoantibodies,24h urine albuminuria and fluorescence fundus angiography are conducted. The relationships levels of thyroid function and diabetic complications are analysed.

Study Type

OBSERVATIONAL

Enrollment

260

Conditions

Diabetes Thyroid Disease

Interventions

no interventionOTHER

This is a cross-sectional study

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients are ≥ 60 years old, with T2DM and the diagnostic criteria of T2DM is according to the World Health Organization in 1999. 2. Patients have normal thyroid function and negative for thyroid autoantibodies, such as thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TGAb). Exclusion Criteria: 1. Patients with a history of thyroid disease or chronic liver disease or nondiabetic renal problems or cancer. 2. Patients use systemic drug therapy such as thyroxine, anti-thyroid drugs, glucocorticoids and oral contraceptives. 3. Patients are pregnant or lactating women. 4. Patients with acute intercurrent illness of diabetes. 5. Patients with an acute infection. 6. Patients with a history of drug abuse alcohol dependence in the past 5 years.

Outcomes

Primary Outcomes

Diabetic retinopathy which is diagnosed by the measurement of fundus fluorescein angiography. (Diabetic retinopathy is clinically graded based on the international clinical diabetic retinopathy severity scales.)

Time frame: Day One

Secondary Outcomes

24h-albuminuria

Time frame: Day One

Data from ClinicalTrials.gov

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