Role of Oxytocin in Myocardial Infarction

Sheba Medical Center52 enrolled

Overview

60 patients admitted to this ICCU at the Sheba medical Center will be randomly divided in to 2 groups. one group will receive the conventional treatment while the second group will receive the conventional treatment plus oxytocin infusion for 48 hours. all participants will undergo echo and cMRI during hospitalization.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Myocardial Infarction

Interventions

OxytocinDRUG

26 patients will receive Oxytocin infusion for 6h while 26 will receive placebo. all other treatments will be the same and up to date with the current guidelines.

PlacebosDRUG

26 patients will receive 0.9% normal saline infusion for 6h as placebo

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 years * current diagnosis of ST elevation myocardial infarction * no previous episodes of acute coronary syndrome * agreed to enter research Exclusion Criteria: * age \< 18 years * congestive heart failure (acute or chronic) * cardiomyopathy * life threatening arrhythmia at presentation * previous LV dysfunction * hypotension (systolic \< 100mmHg, diastolic\<50mmHg, 15% less than patients normal values) * tachycardia - pulse \> 100bpm * bradycardia - pulse \< 55 ppm * killip 3 or 4 at presentation * current use of nitrates * pregnancy * females - history of pathological GU bleeding * inability to give consent

Outcomes

Primary Outcomes

final infarction size

all patients will undergo an cMRI after 7 days

Time frame: 1 week

Secondary Outcomes

Ejection fraction

all patients will undergo echocardiography exam during the first 48 hours

Time frame: 48 hours

Central Contacts

Anat Berkovitch, resident

CONTACT

972545746277 anatberko@gmail.com

Shlomi matetzky, Head of ICCU

CONTACT

972526667122 Shlomi.Matetzky@sheba.health.gov.il

Data from ClinicalTrials.gov

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