Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )

Fundacion Dexeus80 enrolled

Overview

This is a single centre retrospective study in repeated implantation failure patients: \< 39 years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred without implantation, absence of known causes of implantation failures (uterine malformation, thrombophilia, severe male factor, uncontrolled thyroid disfunction, autoimmune disease). Patients scheduled for PGS underwent one or more stimulation cycles (oocyte or blastocyst banking) in order to maximize chances of embryo transfer. PGS cycles are analyzed globally. Aditionally, PGS cycles with a single stimulation cycle are analyzed in comparison to standard IVF cycles.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Infertility Preimplantation Genetic Screening

Interventions

PGS (Preimplantation Genetic Screening) with trophectoderm biopsyPROCEDURE

PGS (Preimplantation Genetic Screening) with trophectoderm biopsy using arrays comparative genomic hybridizatioon (aCGH)

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 Years

Medical Language ↔ Plain English

Inclusion criteria: * women \< 39 years * repeated implantation failure: at least 4 day 3 good quality embryos or 2 good quality blastocysts transferred without implantation Exclusion criteria: * partner with severe male factor, or abnormal sperm Fluorescence in situ hybridization (FISH) analysis * presence of uni or bilateral hydrosalpinx, uterine malformation, thrombophilia, uncontrolled thyroid disfunction or autoimmune disease

Outcomes

Primary Outcomes

Cumulative live birth rate

Time frame: at 24 months of first embryo transfer

Secondary Outcomes

Clinical Pregnancy Rate

Time frame: 6 weeks after embryo transfer

Implantation Rate