FLuid Responsiveness Prediction Using EXtra Systoles

University Medical Center Groningen60 enrolled

Overview

In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload. Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Coronary Artery Bypass Graft

Interventions

fluid challengeOTHER

At two pre-defined time points during the procedure, enrolled patients will receive a fluid bolus of 5 ml/kg during 5 minutes

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients requiring elective CABG or OPCAB surgery * Patient's age ≥ 18 years Exclusion Criteria: * Patient refusal * Pregnancy * EF \< 35% * End stage kidney failure (defined by the need for haemodialysis) * Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)

Locations (1)

Universitu Medical Center Groningen

Groningen, Netherlands

Outcomes

Primary Outcomes

fluid challenge response in stroke volume

To investigate if post-ectopic induced changes in blood pressure before a fluid bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume

Time frame: during operation

Data from ClinicalTrials.gov

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