Autologous Cytokine-induced Killer Cells Combined Chemotherapy in Advanced Pancreatic Cancer

Inclusion Criteria: 1. No less than 18 years old 2. Karnofsky Performance Status over 60 3. Life expectancy more than three months 4. Pathological diagnosed as pancreatic epithelial cell carcinoma 5. Recurrence after surgery or unresectable 6. No experienced chemotherapy or the interval between the last adjuvant chemotherapy and relapse is at least 6 months 7. Measurable lesions (by CT or MRI) 8. No serious mental disorders 9. Adequate organ and bone marrow functions 10. No other serious and the conflict diseases(such as autoimmune diseases, immunodeficiency, organ transplantation) 11. No other malignant tumor history 12. Informed consent and willing to participate in this study Exclusion Criteria: 1. Received immunosuppressants or glucocorticoid treatment 2. Uncontrolled severe infection or unhealed wound caused by suppurative inflammation 3. Heart disease, insufficient heart function, II degree heart block or occurred myocardial infarction in 6 months 4. Poor pulmonary functions caused by interstitial lung disease and pulmonary reserve volume under 80% of the expected value 5. Other malignant tumor history 6. Transaminase\>2.5ULN or bilirubin\>3ULN or creatinine \>1.25ULN 7. Pregnant or lactating women 8. Obvious bleeding tendency 9. Participated other clinical trails in 1 month 10. Other unsuitable conditions: HIV infection, intravenous drug abusers, etc