Continuous Pre-peritoneal Wound Infiltration Versus Epidural Analgesia in Cancer Surgery

Assiut University40 enrolled

Overview

the investigators aim is to investigate the effect of continuous preperitoneal bupivacaine wound infiltration versus epidural analgesia on the inflammatory cytokines response following radical cytectomy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE

Enrollment

Conditions

Abdominal Neoplasms

Interventions

epidural catheterDEVICE

preperitoneal catheterDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-III patients * aged 18-60 yr * undergo open abdominal cancer surgery Exclusion Criteria: * general contraindications for epidural analgesia, * recent history (8 weeks) of, chemotherapy or radiation, * chronic opioid use

Locations (1)

South Egypt Cancer instIitute

Asyut, Egypt

Outcomes

Primary Outcomes

changes in the level of inflammatory cytokines in pg /ml

Blood samples taken all over the 24-hr. period were collected in plasma tubes containing ethyl-enediamine-tetra-acectic (EDTA), centrifuged and stored at 20○c for assessment of Plasma concentrations plasma IL 1, IL 6, IL10 and TNF to assess inflammatory cytokines

Time frame: 24 hours

Secondary Outcomes

Visual Analog Scale at rest and on coughing

pain intensity was assessed using a 10-cm VAS (0 = no pain and 10 = worst imaginable pain)

Time frame: 24 hours

opioid side-effects

observation of side effects and record incidence as nausea, vomiting and itching

Time frame: 24 hours

patient satisfaction

scale ranging 1-4 :unsatisfactory, regular, satisfactory and excellent)

Time frame: 24 hours

Data from ClinicalTrials.gov

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