The P10s-PADRE Basket Trial: Vaccination of Metastatic Cancer Patients

Inclusion Criteria: * Subjects of all races with clinical Stage IV cancer of any type, staged according to American Joint Commission on Cancer (AJCC), sixth edition, receiving any line of standard treatment for the specific cancer and with stable disease or better for at least two months will be invited to participate. * Subjects of all races with clinical Stage IV cancer of any type, staged according to American Joint Commission on Cancer (AJCC), sixth edition, who have no standard treatment options for the specific cancer (Patients whose standard of care consists of watchful waiting) and who fulfill the other eligibility criteria will be invited to participate. * Measurable or evaluable disease. * Patients with bone-only disease will be allowed to participate. * Ages 18 years and older. * ECOG Performance status 0, 1 or 2. * White blood cells (WBC) count ≥ 3,000/mm3 within 3 weeks prior to registration * Platelet count ≥ 100,000/mm3 prior to registration * Serum glutamic-oxaloacetic transaminase (SGOT) ≤ 2 x institutional upper limit (IUL) of normal obtained within 3 weeks prior to registration or Aspartate aminotransferase test (AST) ≤ 2 x institutional upper limit (IUL) of normal obtained within 3 weeks prior to registration * Bilirubin ≤ 2 x institutional upper limit (IUL) of normal obtained within 3 weeks prior to registration. * Serum creatinine ≤ 1.8 mg/dl obtained within 3 weeks prior to registration. * Must sign an informed consent document approved by UAMS Institutional Review Board (IRB). Exclusion Criteria: * Active infection requiring treatment with antibiotics. * Existing diagnosis or history of organic brain syndrome that precludes participation in the full protocol. * Existing diagnosis or history of significant impairment of basal cognitive function that might preclude participation in the full protocol. * Other current malignancies. Subjects with prior history at any time of any in situ cancer, including lobular carcinoma in situ of the breast, cervical cancer in situ, atypical melanocytic hyperplasia or Clark I melanoma in situ, or basal or squamous skin cancer are eligible, provided they are disease-free of these other malignancies at the time of registration. Subjects with other malignancies - other than the one for which they are being treated - are eligible if they have been continuously disease free (from the old cancer) for ≥ 5 years prior to the time of registration. * Existing diagnosis or history of autoimmune disorders or conditions of immunosuppression. This includes, but is not limited to, being treated with corticosteroids, including oral steroids (i.e. prednisone, dexamethasone \[except when used as an antiemetic in standard therapy\]), continuous use of topical steroid creams or ointments or any steroid-containing inhalers. Subjects who have been on systemic steroids will require a 6-week washout period. Subjects who discontinue the use of these classes of medication for at least 6 weeks prior to registration are eligible if, in the judgment of the treating physician, the subject is not likely to require these classes of drugs during the treatment period. Replacement doses of steroids for subjects with adrenal insufficiency are allowed. * Pregnancy or breast feeding, due to the unknown effects of peptide/mimotope vaccines on a fetus or infant. Women of childbearing potential must have a negative urine pregnancy test within 72 hours prior to receiving the first dose of study drug, and must be counseled to use an accepted and effective method of contraception while on treatment and for a period of 18 months after completing or discontinuing treatment. Accepted methods include oral contraceptives, barrier method, IUDs, and abstinence. * Any other significant medical or psychiatric conditions which, in the opinion of the enrolling investigator, may interfere with consent or compliance of the treatment. * Patients receiving checkpoint inhibitors.