The heart rate variability (HRV) is a measure of the autonomic nervous system (ANS). In the model of anorexia nervosa, ANS is disturbed with mostly a predominance of activation of the parasympathetic nervous system and a decrease of the sympathetic system. Various explanations of this these dysfunctions are proposed in literature, mainly malnutrition, physical hyperactivity, anxiety, that are known characteristics of anorexia nervosa. The primary aim of this study is to evaluate correlation between ANS dysfunction and anxiety in anorexia nervosa. Other objectives of this study are firstly to evaluate correlation between ANS dysfunction and others parameters (weight, body mass index, depression, physical activity, purgative ou restrictive type, duration of disease, smoking) in anorexia nervosa and secondly to see if HRV is a predictive parameter of the evolution of anorexia nervosa.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
13
The intervention consist in monitoring the heart rate variability during one night by using a heart rate monitor and a Polar RS800CX
Hospices Civils de Lyon
Bron, France
Statistical correlation between autonomic dysfunction (measured by HRV) and anxiety (measured by questionnaire)
The composite measure consists of the following :- Time and spectral-domain measures of HRV measured by nocturn registration with heart rate monitor and polar RS800CX Time domain - NN (normal-to-normal R-R interval), HRV index (total number of all NN/ the height of the histogram of all NN), SDNN (standard deviation of the NN), RMSSD (the root mean square of differences of successive NN), NN50 (Number of pairs of adjacent NN intervals differing by more than 50 ms in the entire recording) and pNN50 (NN50/total number of all NN), SDANN (Standard deviation of the average of NN intervals in all 5-minute segments of a long recording), SDNNIDX (Mean of the standard deviation in all 5-minute segments of a long recording) Frequency domain - VLF Power (very low frequency; \<0.04 Hz), LF Power (low frequency; 0.04\~0.15 Hz), HF Power (high frequency; 0.15\~0.4 Hz), LF/HF ratio value \- State-Trait Anxiety Inventory: version Y (STAI- form Y) - Morning blood cortisol level and serum prealbumin lev
Time frame: at day 0
Statistical correlation between autonomic dysfunction (measured by HRV) and measures of Beck Depression inventory
Beck Depression inventory : Version 2 in french (BDI-II)
Time frame: at day 0
Statistical correlation between autonomic dysfunction (measured by HRV) and measures of Beck Depression inventory
Beck Depression inventory : Version 2 in french (BDI-II)
Time frame: at 6 months
Statistical correlation between autonomic dysfunction (measured by HRV) and measures of International physical activity questionnaire
International physical activity questionnaire (IPAQ) - French version
Time frame: at 6 months
Statistical correlation between autonomic dysfunction (measured by HRV) and measures of International physical activity questionnaire
International physical activity questionnaire (IPAQ) - French version
Time frame: at day 0
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