Investigation of the acute and chronic effects of Supradyn® Energy 3RDA on subjective ratings of 'fatigue/stress', substrate metabolism and blood biomarkers of recovery, as a consequence of exercise and metabolically demanding cognitive tasks.
Supplementation with vitamins and minerals has been shown to enhance energy production, metabolism, and mood state. It is thought that they may also aid recovery from challenging physical and psychological tasks following both acute and chronic supplementation. The present study will investigate the effects of a multivitamin/mineral supplement (Supradyn® Energy 3RDA) following a single intake and following daily intake for 4-weeks on subjective ratings of 'fatigue/stress', metabolism and blood biomarkers of cell damage following both exercise and demanding cognitive tasks, in healthy young male and female volunteers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
91
Multivitamin/mineral containing co-Q10
Placebo
Northumbria University
Newcastle upon Tyne, Tyne & Wear, United Kingdom
Acute treatment effects on energy expenditure/metabolism during physical stress
ICa (Indirect Calorimetry) data obtained to determine energy expenditure, fat and carbohydrate oxidation
Time frame: Measures taken following acute treatment during exercise (45 minutes post acute treatment)
Acute treatment effects on energy expenditure/metabolism during mental stress
ICa (Indirect Calorimetry) data obtained to determine energy expenditure, fat and carbohydrate oxidation
Time frame: Measures taken following acute treatment during cognitive task performance (135 minutes post acute treatment)
Chronic treatment effects on energy expenditure/metabolism during physical stress
ICa (Indirect Calorimetry) data obtained to determine energy expenditure, fat and carbohydrate oxidation
Time frame: Measures taken following 28 days' chronic treatment, during exercise performance
Chronic treatment effects on energy expenditure/metabolism during mental stress
ICa (Indirect Calorimetry) data obtained to determine energy expenditure, fat and carbohydrate oxidation
Time frame: Measures taken following 28 days' chronic treatment, during cognitive task performance
Acute treatment effects on subjective arousal/stress/fatigue ratings as assessed by visual analogue scales during physical stress
Subjective ratings of arousal (concentration, mental stamina/physical stamina) stress and fatigue (mentally tired/physically tired) visual analogue scales (scored along 100mm line)
Time frame: Following acute treatment, measures taken before, after and every 10 minutes during 30 minute exercise period
Acute treatment effects on subjective arousal/stress/fatigue ratings as assessed by visual analogue scales during mental stress.
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Subjective ratings of arousal (concentration, mental stamina/physical stamina) stress and fatigue (mentally tired/physically tired) visual analogue scales (scored along 100mm line)
Time frame: Following acute treatment, measures taken before, after and every 10 minutes during 30 minute cognitive task period
Chronic (28 days) treatment effects on subjective arousal/stress/fatigue ratings as assessed by visual analogue scales, during physical stress
Subjective ratings of arousal (concentration, mental stamina/physical stamina) stress and fatigue (mentally tired/physically tired) visual analogue scales (scored along 100mm line)
Time frame: Following 28 days' treatment, measures taken before, after and every 10 minutes during 30 minute exercise period
Chronic (28 days) treatment effects on subjective arousal/stress/fatigue ratings as assessed by visual analogue scales, during mental stress
Subjective ratings of arousal (concentration, mental stamina/physical stamina) stress and fatigue (mentally tired/physically tired) visual analogue scales (scored along 100mm line)
Time frame: Following 28 days treatment, measures taken before, after and every 10 minutes during 30 minute cognitive task period
Acute treatment effects on recovery biomarkers
Measuring levels of Interleukin-6, F2 isoprostanes, protein carbonyls, C-reactive protein, glutathione peroxidase, taken to assess recovery from exercise
Time frame: Following acute treatment, taken at baseline and following exercise (75 minutes post-dose) and cognitive task performance (165 minutes post-dose). Then at 24h and 48hours post-exercise.
Chronic (28 days) treatment effects on recovery biomarkers
Measuring levels of Interleukin-6, F2 isoprostanes, protein carbonyls, C-reactive protein, glutathione peroxidase, taken to assess recovery from exercise
Time frame: Following 28 days treatment, taken at baseline, following exercise and cognitive task performance. Then at 24h and 48hours post-exercise.
Acute treatment effects on vitamin/mineral/homocysteine levels
Measuring levels of Ferritin, vitamin B12, homocysteine, creatinine
Time frame: Measured at baseline, then following acute treatment, after exercise (75 minutes post-dose)
Chronic (28 days) treatment effects on vitamin/mineral/homocysteine levels
Measuring levels of Ferritin, vitamin B12, homocysteine, creatinine
Time frame: Following chronic (28 days) treatment, measured after exercise
Acute treatment effects on cognitive performance
Tasks include serial 3s, serial 7s and RVIP (Rapid Visual Information Processing), repeated 3 times
Time frame: Following acute treatment, measured 135 minutes post dose
Chronic (28 days) treatment effects on cognitive performance
Tasks include serial 3s, serial 7s and RVIP (Rapid Visual Information Processing), repeated 3 times
Time frame: Following chronic (28 days) treatment