Glycemic Index Variation During Low-carbohydrate Enteral Formula With and Without Fructose in Critically Ill Patients

Hospital Moinhos de Vento25 enrolled

Overview

Hyperglycemia is a known risk factor for mortality in critically ill patients. Most of these patients receive enteral feeding. There is controversy about ideal carbohydrate composition of these diets. The aim of this study was to compare an enteral formula with the same proportion of carbohydrates with and without fructose on blood glucose levels.

Randomized, cross-over, controlled, double-blind clinical trial without washout. Adult patients admitted to the ICU who presented capillary glycemia values\> 180mg / dl with a full and exclusive enteral diet. They were randomized and observed for 4 days (2 days with each diet: with / without fructose). Capillary glycemia was measured 4 / 4h.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Critical Illness

Interventions

Enteral Formula With FructoseDIETARY_SUPPLEMENT

Low-carbohydrate Enteral Formula With Fructose

Enteral Formula Without FructoseDIETARY_SUPPLEMENT

Low-carbohydrate Enteral Formula Without Fructose

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Critical Illness * Exclusive enteral diet * Enteral diet with full nutritional value * Hyperglycemia ≥180 mg / dl Exclusion Criteria: * Oral feeding * NPT (Total or Partial Parenteral Nutrition) * Patient without indication of use of study diets

Outcomes

Primary Outcomes

Glycemic Variability

To evaluate the glycemic oscillation during the use of enteral feedings

Time frame: four days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.