Supervised Exercise-training in Children With Insulin Resistance or Healthy Metabolic Profile

Universidad Santo Tomas60 enrolled

Overview

Despite exercise training decrease blood fasting glycemia in 'average' terms, there is a wide interindividual variability after exercise training explored mainly in adults but not in children. Thus, is yet unknown what baseline health status as well as the influence of what health variable may produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some metabolic outcomes) after exercise training in school children.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Metabolism Disorder Insulin Sensitivity Obesity, Pediatric

Interventions

Control groupBEHAVIORAL

Post statistical analyses will be including analyses by the 3 sub-groups proposed Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 6 weeks.

Eligibility

Sex: ALLMin age: 9 YearsMax age: 13 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed of insulin resistance by one of three plasmatic glucose control: HOMA-IR ≥3.0, * Fasting insulin levels ≥15 µUI/dL or fasting glucose ≥100 and ≤126 mg/dL within the enrolment stage applied at school (i.e., ≤3 months), * Physical inactivity (volume of ≤60 min/day of moderate physical activity), * To be participating of regular practical physical education classes at school (i.e., 90 min/week), * Living only in urban areas. Exclusion Criteria: * Potential medical, musculoskeletal problems or a familial history of T2DM, * Ischemic disease, * Arrhythmia, * Asthma, * Utilization of drugs that modulate the metabolic and respiratory control.