Physiological Effects of Creatine Supplementation in Active Males

Texas A&M University48 enrolled

Overview

This study was designed to examine how different forms of creatine impact active males.

This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE

Enrollment

Conditions

Dietary Supplementation

Interventions

Creatine monohydrateDIETARY_SUPPLEMENT

Creatine monohydrate (6.0 g) + dextrose (0.5 g)

Creatine nitrateDIETARY_SUPPLEMENT

Creatine nitrate (5.0 g creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio)

PlaceboDIETARY_SUPPLEMENT

Placebo (6.5 g dextrose)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * participants are apparently healthy and recreationally active males between the ages of 18 and 40; * participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat; Exclusion Criteria: * participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease; * participants are currently using prescription medications; * participants have a history of smoking; * participants drink excessively (i.e., 12 drinks per week or more); * participants have a recent history of creatine supplementation within six weeks of the start of supplementation;

Outcomes

Primary Outcomes

Effects of 28 Days of Different Forms of Creatine Supplementation on Body Water

Assessing Body Water through Bioelectrical Impedance Analysis (BIA)

Time frame: 28 Days

Effects of 28 Days of Different Forms of Creatine Supplementation on Body Composition

Assessing Body Compositing through Dual-Energy X-Ray Absorptiometry (DXA)

Time frame: 28 Days

Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular creatine

Assessing intramuscular creatine using standard spectrophotometric methods using a microplate spectrophotometer

Time frame: 28 Days

Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular phosphocreatine

Assessing intramuscular phosphocreatine using standard spectrophotometric methods using a microplate spectrophotometer

Time frame: 28 Days

Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular ATP

Assessing intramuscular Adenosine Triphosphate (ATP) using standard spectrophotometric methods using a microplate spectrophotometer

Time frame: 28 Days

Effects of 28 Days of Different Forms of Creatine Supplementation on muscular strength

Assessing muscular strength through 1 Repetition Maximum (RM) testing

Time frame: 28 Days

Effects of 28 Days of Different Forms of Creatine Supplementation on muscular endurance

Assessing muscular endurance through repetition to failure testing

Time frame: 28 Days

Data from ClinicalTrials.gov

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Physiological Effects of Creatine Supplementation in Active Males

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes