Daptomycin Concentration in Drainage Fluid and Blood Samples of ICU Patients

University Hospital Tuebingen9 enrolled

Overview

10 patients with chronic heart failure receiving daptomycin therapy after implantation of a left ventricular heart assist system. Measurement of daptomycin levels in drainage fluids (mediastinal and pleural drainage systems) and in blood samples.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Assist Device

Interventions

DaptomycinDRUG

standard care

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * written consent * heart assist device implantation * wound drainage * daptomycin therapy Exclusion Criteria: * pregnancy * no written consent possible * absence of wound drainage * allergy to study medication * acute rhabdomyolysis

Locations (1)

University Hospital Tuebingen

Tübingen, Germany

Outcomes

Primary Outcomes

levels of Daptomycin in drainage fluid

Pharmacokinetics of Daptomycin in intensive care patients with wound drainage after surgery (LVAD implantation)

Time frame: 4 days

levels of Daptomycin in blood samples

Pharmacokinetics of Daptomycin in intensive care patients after surgery (LVAD implantation)

Time frame: 4 days

Secondary Outcomes

infections

incidence of gram-positive infections

Time frame: 14 days

Data from ClinicalTrials.gov

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