Prevention of Ischemic Conditions in Non-disabling Stroke/Transient Ischemic Attack With Remote Ischemic Conditioning

Inclusion Criteria: 1. Eighteen years old or older of any gender or race; 2. Diagnosed with a non-cardiogenic MIS/TIA within 14 days; MIS is defined by an ischemic stroke of score of 3 or less on the NIHSS at the time of inclusion, TIA is defined as neurologic deficit attributed to focal brain ischemia, with symptoms resolution within 24 h of symptom onset, Symptom onset is defined by the "last see normal" principle; 3. Stable vital signs, normal cardiac, hepatic and renal functions; 4. Able to consent by himself/herself or by legally authorized representative. Exclusion Criteria: 1. Diagnosis of hemorrhage or other pathology, such as vascular malformation, tumor, abscess or other non-vascular diseases, based on brain CT or MRI; 2. Modified Rankin Scale score \> 2 at inclusion; 3. Received iv. recombinant tissue plasminogen activator (rtPA) therapy or interventional treatment for the current event; 4. Contradiction for aspirin or clopidogrel (known allergy, severe asthma or heart failure et al.) ; 5. Clear indication for anticoagulation therapy ( cardiac source of embolus); 6. Hemorrhagic tendency of any reason （including but not limit to Hemostatic disorder, platelet count \<100 × 109/L, history of drug-induced hepatic dysfunction）; 7. Any hemorrhagic transformation; 8. Gastrointestinal bleed or major surgery within 3 months of symptoms onset; 9. Stroke or TIA induced by interventional therapy or surgery; 10. Any upper extremity soft tissue, vascular injury or peripheral blood vessel disease which may contraindicate RIC; 11. Systolic blood pressure greater than 200 mmHg after medication; 12. Planned revascularization (any angioplasty or vascular surgery) within the next 3 months ； 13. Scheduled for surgery or interventional treatment requiring RIC cessation within next 3 months; 14. Severe noncardiovascular comorbidity with life expectancy \< 3 months; 15. Pregnancy; 16. Currently receiving an investigational drug or device by other studies.