StrataGraft® Skin Tissue as an Alternative to Autografting Full-thickness Complex Skin Defects

Inclusion Criteria: 1. Men and women aged 18-65 years, inclusive 2. Written informed consent 3. Sufficient healthy skin identified and reserved as a donor site in the event that the StrataGraft treatment site requires autografting 4. Complex skin defects of up to 49% Total Body Surface Area (TBSA) requiring excision and autografting * Total skin defect may consist of more than one wound area 5. Full-thickness complex skin defects requiring excision and autografting 6. Study treatment sites on the torso and limbs may be up to 200 cm2 in cohort 1 and 400 cm2 in cohort 2 7. For thermal burns only, first excision and grafting of treatment sites Exclusion Criteria: 1. Pregnant women and prisoners 2. Subjects receiving systemic immunosuppressive therapy 3. Subjects with a known history of malignancy 4. Preadmission insulin-dependent diabetic subjects 5. Subjects with concurrent conditions that in the opinion of the investigator may compromise subject safety or study objectives 6. Expected survival of less than three months 7. Participation in the treatment group of an interventional study within the 90 days prior to enrollment 8. Chronic wounds 9. The face, head, neck, hands, feet, buttocks, perineum, and area over joints 10. Treatment sites with exposed tendon or bony prominences 11. Chemical and electrical burns 12. Treatment sites adjacent to unexcised eschar 13. Clinical suspicion of infection at the anticipated treatment sites