Gender and Opioid Consumption

Mansoura University100 enrolled

Overview

Opioids are widely used for pain relief after major abdominal surgeries\[1\]. Sex differences in the opioid analgesia have been reported and investigated in human subjects and animal models In this study, effects of sex difference on response to opioid analgesics after abdominal surgeries will be assessed regarding; analgesic duration (primary variable), frequency of analgesic requirement, total opioid consumption, Opioid related complications (respiratory depression, Nausea \& vomiting, itching, over-sedation, delayed intestinal motility).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

100

Conditions

Postoperative; Parotitis

Interventions

postoperative morphineDRUG

Postoperatively, A loading dose of morphine will be given in incremental doses of 1 mg 5 min apart, till the VAS score reached ≤3. The dose of morphine required to reduce the VAS score to ≤3 will be recorded. Subsequently, PCA pump will be configured to deliver a bolus of 1 mg with a lock-out period lasting for 20 min.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I and II Cases scheduled for elective intraabdominal surgeries Exclusion Criteria: * diabetes, * postmenopausal females, * laparoscopic surgery, * regional anesthesia emergency procedures, * sepsis, * hepatectomy, * Renal impairment, and * hepatic impairment, * mental and psychiatric disorders.

Outcomes

Primary Outcomes

postoperative morphine consumption

Time frame: 24 hours after surgery

Data from ClinicalTrials.gov

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