Genetic Variation in Gonadotropin and Gonadotropin Receptor Genes and Suboptimal Response

Fundacion Dexeus364 enrolled

Overview

To evaluate the difference in the prevalence of the main FSHR polymorphism (ASN680Ser), as well as other, less studied, gonadotropin polymorphisms between ovarian response groups, following ovarian stimulation

Study Type

OBSERVATIONAL

Enrollment

364

Conditions

Fertility Disorders

Interventions

blood sampleOTHER

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age between 18-38 years old 2. BMI 18-28 3. Antral follicle count (AFC) \> 9 or Anti-mullerian hormone (AMH) \>1.1 ng/ml 4. 1st or 2nd ovarian stimulation cycle for IVF/ICSI 5. Planned to undergo ovarian stimulation with 150IU of rFSH in a fixed GnRH antagonist protocol Exclusion Criteria: 1. Antral follicle count (AFC) \<9 and AMH\<1.1 ng/ml 2. PCOS patients according to the Rotterdam criteria 3. Patients undergoing in vitro maturation (IVM) 4. Untreated endocrine abnormalities

Locations (2)

Dexeus Salud de la Mujer

Barcelona, Spain

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy HCMC, Ho Chi Minh City, Vietnam and Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University HCMC

Ho Chi Minh City, Vietnam

Outcomes

Primary Outcomes

prevalence of the main FSH receptor polymorphism

Time frame: 12 months

Data from ClinicalTrials.gov

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