Preimplant Site Augmentation Using MPM Versus Autogenous Bone Graft

Cairo University20 enrolled

Overview

Using growth factors obtained from patient's venous blood mixed with particulate autogenous bone the study compares bone gain by implant with gold standards.

To study the effectiveness of MPM in ridge augmentation with implant insertion compared with autogenous bone graft. -PICO- Population (P): Patients with defective maxillary alveolar ridge requiring implant insertion. Intervention (I): Ridge augmentation with MPM. Comparator (C): Autogenous bone graft. Outcome (O): Patient satisfaction - Implant stability.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Bone Resorption

Interventions

Mineralized plasmatic matrix (MPM).OTHER

By using venoud blood from the patient, together with bone graft, a centrifuge will be used to obtain the top layer after centrifuging blood at 3000 RPM, for 10 minutes , Which will result if sticky bone graft consistency after mixing.

Autogenous bone graft (gold standard).OTHER

Exposed implant threads are to be covered with autogenous bone and collagen membrane.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Medically free patients. 2. Evaluated bone height on CBCT to be (0-4 mm buccal bone dehiscence) and width (not less than 4.5 mm) 3. Patients with Anterior maxillary defective partially edentulous ridge. 4. Age between 18 and 40 years. 5. Both sexes. 6. Patients physically able to tolerate surgical and restorative procedures. 7. Patients with an opposing tooth to the pre-implant site. 8. Good oral hygiene. 9. Highly motivated patients. Exclusion Criteria: 1. Patients allergic to local anesthetic agent. 2. Pregnant or lactating females. 3. Presence of any pathosis in the pre-implant site. 4. Presence of any mucosal disease. 5. Presence of parafunctional habits. 6. History of oral radiotherapy. 7. History of prolonged steroids use. 8. Psychological disorders.

Outcomes

Primary Outcomes

Patient Satisfaction regarding esthetic results , outcome will be measure using questionnaire.

Time frame: 5 months

Secondary Outcomes

Stability of dental implants , this will be measured using Ostell device in ISQ units.

Time frame: 5 months.

Data from ClinicalTrials.gov

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