The Study of Conversion Surgery for Apatinib in Combination With SOX for Patients With Unresectable Gastric Cancer

Inclusion Criteria: 1. Histologically proved gastric adenocarcinoma; 2. At least a unresectable factor before operation via CT, MRI, or PET-CT: difficult resection of locally advanced gastric cancer(T4b); hepatic metastasis (H1; at most five lesions, total diameter ≤8 cm); Peritoneal metastasis(CY1, P1) ; 3. Definitely diagnosed as unresectable gastric cancer via exploratory laparoscopy or laparotomy; 4. ECOG performance status 0-2; 5. Age 18-70 years old, Life expectancy estimated than 3 months; 6. For results of blood routine test and biochemical tests: 1. Hgb ≥ 80g/L, 2. WBC ≥ 4000/mm3, 3. ANC ≥ 1.5×109/L, 4. platelets ≥ 80×109/L 5. ALT and AST ≤ 2.5 x upper normal limit (UNL), and ≤ 5 x UNL（Hematogenous metastases）, 6. Serum Total bilirubin ≤ 1.5 X UNL, 7. Serum Creatine ≤ 1.5 x UNL ； 7. Good cardiac function before the recruitment, no seizure of myocardial infarction in past half years, and controllable hypertension and other coronary heart disease; 8. Not concomitant with other uncontrollable benign disease before the recruitment(e.g. the infection in the kidney, lung and liver); 9. informed consent. Exclusion Criteria: 1. Subjects with poor-controlled arterial hypertension (systolic blood pressure\> 140 mmHg and diastolic blood pressure \> 90 mm Hg) despite standard medical management; Coronary heart disease greater than Class I; I-level arrhythmia (including QT interval prolongation, for man ≥ 450 ms, for woman ≥ 470 ms) together with Class I cardiac dysfunction; Patients with positive urinary protein; 2. Factors that could have an effect on oral medication (such as inability to swallow, chronic diarrhea and intestinal obstruction); 3. Subjects with high gastrointestinal bleeding risk, including the following conditions: local active ulcer lesions with positive fecal occult blood test (++); history of black stool, or vomiting blood in the past 2 months; 4. Contraindications include allergy to apatinib and/or its accessories, active bleeding, intestinal perforation, intestinal obstruction, within 30 days after surgery, drugs with poor-controlled hypertension, Class Ⅲ-Ⅳ cardiac dysfunction （NYHA standard）, severe hepatic and renal dysfunction（level 4）if apatinib use is considered; 5. Abnormal Coagulation (INR\>1.5, APTT\>1.5 UNL), with tendency of bleed; 6. Pregnant or lactating women; 7. Any other condition that might place the patient at undue risk or preclude a patient from completing the study; 8. Treatment with prior radiotherapy, chemotherapy, Targeted therapy or immunotherapy; 9. Other conditions regimented at investigators' discretion.