Phase II/III Trial of CCRT With or Without JP001 for Newly Diagnosed GBM

Inclusion Criteria: 1. Subjects with histologically proven newly diagnosed case of GBM (WHO grade IV) and treatment-naive (chemotherapy and radiotherapy) for GBM. Diagnosis must be made by stereotactic biopsy or surgical excision, either partial or complete within 3 months prior to Visit 1. 2. Subject's RPA class is class III, IV or V. 3. Subjects with stereotactic biopsy or brain surgery must be suited for or will be scheduled for CCRT followed by Temozolomide treatment, the standard treatment recommended by institutes and fulfilled the reimbursement guideline of National Health Insurance Administration. 4. Subjects must have recovered from the effects of surgery, post-operative infection, and other complications prior to Visit 1. Study treatment must be performed \> 3 weeks and ≤ 8 weeks after craniotomy. Ventricular fluid reservoir or Ventriculo-Peritoneal shunting tube is allowed to keep. 5. A diagnostic contrast-enhanced MRI of the brain must be performed postoperatively within 28 days prior to Visit 2 (Day 1). 6. ECOG performance status ≤ 3 at Visit 1. 7. Age from 20 to 80 years old at Visit 1. 8. Life expectation ≥ 12 weeks at Visit 1. 9. CBC/differential obtained at Visit 1, with adequate bone marrow function defined as follows: 1. Absolute neutrophil count (ANC) ≥ 1,500 cells/mm3 (1.5 x 109/L) or white blood cell (WBC) ≥ 3,000 cells/mm3 (3 x 109/L). 2. Platelets count ≥ 100,000 cells/mm3 (100 x 109/L). 3. Hemoglobin (Hgb or Hb) ≥ 10.0 g/dL (100 g/L) (Note: The use of transfusion or other intervention to achieve Hemoglobin ≥ 10.0 g/dL (100 g/L) is acceptable). 10. Adequate renal function, as defined below: a. Creatinine ≤ 1.5 times upper laboratory limit at Visit 1. 11. Adequate hepatic function, as defined below: 1. Total Bilirubin ≤ 2.0 mg/dL (34.20 umol/L) at Visit 1. 2. ALT ≤ 3 times upper laboratory limit at Visit 1. 3. AST ≤ 3 times upper laboratory limit at Visit 1. 12. Subjects is able to understand and willing to comply with the study procedures and has signed the informed consent form (ICF). Exclusion Criteria: 1. Other invasive malignancy. However, subject with other invasive malignancy that have been disease-free more than or equal to 10 years and deemed no need for anti-cancer treatments can be recruited. Subjects with noninvasive malignancy, including carcinoma in situ of the breast, non-melanomatous skin cancer and cervix carcinoma in situ can be recruited if disease-free and treatment free more than or equal to 3 years. 2. Metastases detected beyond the cranial vault. 3. Subjects with the following history: 1. Brain irradiation or Temozolomide usage. 2. Macular degeneration or retinopathy. 3. Renal transplantation. 4. Subjects are currently receiving any anti-rejection medicine or Hydroxychloroquine sulfate for rheumatoid arthritis. 5. Subjects with severe and active co-morbidity, defined as follows: 1. Clinical active kidney, liver, lung or cardiac disease. 2. Acute bacterial or fungal infection requiring intravenous antibiotics at Visit 1 and acquired immune deficiency syndrome (AIDS). 3. Any active infection or uncontrolled infection at Visit 1. 4. Abnormal CXR finding with risks of infection and interstitial lung disease/pneumonitis. 6. Pregnant or lactating women, due to possible adverse effects on the developing fetus or infant from study drug. 7. Mean QTc \> 500 msec (with Bazett's correction), history of familial long QT syndrome or other significant ECG abnormality noted at Visit 1. 8. Known hypersensitivity reactions to Temozolomide, dacarbazine (DTIC), hydroxychloroquine, 4-aminoquinoline, rapamune, sirolimus, rapamycin, or their analogs. 9. Women of child-bearing potential or men who are able to father a child unwilling to use a. medically acceptable method of contraception during the trial. 10. Subjects participated in another investigational agent study in the past 30 days or are planning to do so during the study period. 11. Subjects are considered ineligible for the study as judged by the investigator. 12. Subjects with positive HBsAg or positive anti-HCV.