Effect of FDG-PET/CT for Simulation and Radiation Treatment Planning in Oral Cancer Patients

Zhongnan Hospital100 enrolled

Overview

This study evaluates the effect of FDG-PET/CT for Simulation and Radiation Treatment Planning in oral Cancer patients. Progress-free survival (PFS) will be compared with historical control as defined in the protocol

Radiotherapy improves local control and overall survival for oral cavity cancer patients after surgery. However, limited locoregional control remains a key issue in the management of oral cavity carcinomas. Appropriate target selection is a key issue in the radiotherapy of oral cavity cancer. The purpose of this study is to determine the locoregional control in PET/CT based radiotherapy treatment planning in the treatment of oral cancer

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Oral Cancer Radiotherapy; Complications

Interventions

PET/CTDEVICE

pet/ct is used as radiotherapy simulation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologically confirmed oral squamous-cell carcinoma * Age \> 17 years * Signed informed consent * ECOG Performance status 0-2 * Must be able to start RT within 4 weeks after PET/CT simulation Exclusion Criteria: * stage IV disease diagnosed before acquisition of staging PET/CT * prior radiotherapy to oral and neck * Unable to understand study participation * Claustrophobia * pregnant or breast feeding mothers

Outcomes

Primary Outcomes

progress free survival

Time frame: baseline to 2 years

Data from ClinicalTrials.gov

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