A Registry Study on Genetics and Biomarkers of Thoracic Aortic Aneurysm/Dissection

Beijing Institute of Heart, Lung and Blood Vessel Diseases600 enrolled

Overview

This is a national registry study to determine genetic risk factor and serial biomarkers of thoracic aortic aneurysm/dissection

Study Type

OBSERVATIONAL

Enrollment

600

Conditions

Aortic Aneurysm, Thoracic Aneurysm, Dissecting

Eligibility

Sex: ALLMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Case Inclusion Criteria: 1. Subject who was diagnosed as thoracic aortic aneurysm/dissection by CT angiography, interventional angiography or vascular ultrasound; 2. Age is less than 80 years old; 3. male and non pregnancy female; 4. Subject understands study requirements aand agrees to sign an informed consent form prior to any study procedures. Case Exclusion Criteria: Subject has one of the following: 1. Pseudoaneurysm; 2. Previous infection or trauma in the damaged part of aorta; 3. Pregnancy female; 4. Participate in other clinical trials in the last 1 months. Control Inclusion Criteria: 1. Age and gender are matched with cases; 2. No aortic disease was detected by outpatient ultrasound; 3. No family history of cardiovascular disease; 4. Normal biochemical indicators; Criteria for culling, shedding and suspension testing: 1. Culling: Unqualified cases and controls. Data of culled subjects can not be used for statistical analysis; 2. Shedding: Subject that self withdrawal, loss to follow-up, or quitted by doctors; Reasons for shedding should be indicated for each shed subject. 3. Suspension: a) The researchers found significant safety problems or wrong study design; b) Researchers cannot continue clinical research due to funding or management reasons; c) Director ends the study. When suspension happens, all the CRF table should be reserved for future reference.

Locations (1)

Beijing Anzhen Hospital

Beijing, China

RECRUITING