Comparative Pharmacokinetics and Food-Effect Bioavailability of Lubiprostone Sprinkle in Healthy Volunteers

Inclusion Criteria: * Is male or female, between 18 and 55 years of age, inclusive. * Has a 12-lead electrocardiogram (ECG) within normal limits and is in good health based upon review of medical history, physical examination results, vital signs (within normal range), and normal laboratory profile for both blood and urine. Exclusion Criteria: * Has an active or recent history of alcoholism or drug addiction (within 1 year prior) * Is a smoker or has a recent history of smoking (within 6 months) * Routinely consumes food known to alter drug metabolism (i.e., grapefruit juice, coffee, tea, cola, chocolate, cocoa, or other caffeine or methyl-xanthine containing foods or beverages) and/or cannot refrain from these items * Has donated blood within 3 months * Has a medical/surgical condition that might interfere with the absorption, distribution, metabolism, or excretion of the study medication.