The Effect of Pasteurized; Pasteurized and Homogenized and UHT Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults

University of Turku14 enrolled

Overview

This study aims to investigate differences in digestion rates and gastrointestinal problems caused by pasteurized; pasturized and homogenized as well as UHT-treated homogenized cow's milks in healthy adults by diary of symptoms, blood glucose and triacylglycerol levels and plasma cytokine levels.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Unidentified Gastrointestinal Discomfort Following Dairy Consumption

Interventions

Dietary interventionOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Homogenized and pasteurized milk causes gastrointestinal problems (self-reported) unhomogenized and unpasteurized milk does not cause gastrointestinal problems (self-reported) * age 18-65 * BMI 18,5 - 30 * hemoglobin under normal range * fasting plasma alanine aminotransferase ALAT \< 60 U/l (normal liver function) * fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function) * fasting plasma creatinine \< 118 umol/l (normal kidney function) Exclusion Criteria: * pace maker * Crohn's disease or other disease of the intestinal tract * intestinal operation within the last 3 months * difficult dysphagia * smoking * constipation * lactose intolerance * coeliac disease

Locations (2)

Department of Biochemistry, University of Turku

Turku, Finland

Food Chemistry, Department of Biochemistry, University of Turku

Turku, Finland

Outcomes

Primary Outcomes

Gastrointestinal symptoms (self reported)

Gastrointestinal symptoms (self-reported) as measured by a questionnaire. The questionnaire is devided into seven types of gastrointestinal discomfort, and also includes a possibility to describe a gastrointestinal discomfort outside these seven given alternatives. The severity of the symptoms is self-reported on a three-step scale.

Time frame: day 0 - day 5

Secondary Outcomes

Plasma triacylglycerols

Time frame: 20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min

Plasma glucose

Time frame: 20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min

Plasma insulin

Time frame: 20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min

Data from ClinicalTrials.gov

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