Neural Injury in Adolescents With Concussion

N/ACompletedNCT03011983

Children's Hospital of Philadelphia4 enrolled

Overview

This study utilizes multimodal brain imaging to obtain quantitative biomarkers of brain injury and to improve understanding of the biological basis of brain pathology in adolescents with concussion. Adolescents with a concussion will undergo neuroimaging and neuropsychology assessments acutely and four months after injury.

Concussion is a highly prevalent condition in adolescence, but it remains a clinical diagnosis that largely relies on subjective patient report with no reliable objective biomarkers for diagnosis. Traditional clinical brain imaging has not been found useful for concussion as the pathology is generally not visible on conventional acute MRI or CT. The proposed study addresses this gap in concussion diagnosis and management by examining the sensitivity of magnetoencephalography (MEG) for identifying areas of brain injury through detection of abnormal neural activity (slowing) in adolescents with concussion compared to healthy controls. Adolescents with a concussion will complete neuroimaging (MEG and MRI) and neuropsychology assessments at two time points within ten days and then again 4 months post-injury. Healthy controls will complete neuroimaging and neuropsychology assessments at a single time point.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mild Traumatic Brain Injury Concussion, Mild Acute Brain Injury

Interventions

MEGDEVICE

MEG is a non-invasive functional imaging technique that can measure slow-wave neural activity.

MRIDEVICE

MRI is a non-invasive imaging modality that provides measures of brain structure.

Neuropsychology assessmentBEHAVIORAL

A battery of tests will be administered by a neuropsychologist to evaluate the cognitive function of adolescents with concussion compared to healthy controls.

Eligibility

Sex: ALLMin age: 12 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of concussion and within 2 weeks of injury (case subjects) * No history of diagnosed concussion (control subjects) Exclusion Criteria: * Head injury within 1 year of recent concussion (case subjects) * History of neurologic, psychiatric, developmental or learning disorders (all subjects)

Locations (1)

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Difference in MEG Whole-Brain Slow-Wave Sensitivity between Controls and Concussion Patients

Whole-brain, resting-state slow-wave maps of whole brain activity will be obtained from the MEG imaging in both adolescents with a concussion and healthy controls. Control images will be analyzed to determine a whole brain z-score value that includes typically developing controls below the 95th percentile, the z-score threshold for this group). Z-score images for the adolescents with concussion will be obtained and the number of adolescents with concussion above this z-score threshold will be determined, and compared to the healthy controls. The sensitivity and specificity of this method determined.

Time frame: Up to 2 months

Secondary Outcomes

Difference in MRI White-Matter Diffusion Measures between Controls and Concussion Patients

MRI diffusion data will be collected to examine associations between abnormal brain slowing and white matter damage in the adolescents with a concussion versus controls. Regions showing abnormal white matter diffusion will be comparing to normative control diffusion data.

Time frame: Up to 2 months

Data from ClinicalTrials.gov

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