Study of Cannabidiol for Drug-Resistant Epilepsies

Inclusion Criteria: 1. Ages between 1 year old and 20 years old, male or female at the first visit, Week -4 (at time informed consent form is signed) 2. Documentation of a diagnosis of drug-resistant epilepsy as proven by and documented with medical records and/or the following clinical features (must have all 3 of the following): 1. Failure to control seizures despite appropriate trial of 3 or more AEDs at therapeutic doses 2. An intractable childhood epilepsy including, Dravet Syndrome or Lennox-Gastaut Syndrome 3. Must report at least 3 countable (non-countable seizures includes absence and myoclonic) seizures per month 3. Between 1-3 baseline AEDs . Vagus nerve stimulator (VNS), ketogenic diet, and modified Atkins diet do not count towards this limit. 4. VNS must be on stable settings for a minimum of 3 months. 5. If on the ketogenic diet, must be on stable ratio for a minimum of 3 months. Exclusion Criteria: 1. Epilepsies associated with neurodegenerative diseases, including neuronal ceroidolipofuscinosis, progressive myoclonus epilepsies, Rasmussen encephalitis, and tumors 2. Epilepsies associated with an inborn error of metabolism, including mitochondrial disorders 3. Felbatol initiated within the past 12 months 4. Use of any Cannabis-related product (including hemp oil) in the past 12 months as assessed by parental questioning. 5. Laboratory values on comprehensive metabolic panel (CMP) and complete blood count (CBC) testing that are Class 3 or higher according to the CTCAE v4.0. 6. Positive pregnancy test.