The principal objective of the study is to measure parameters of inflammation, oxidative stress, and vascular, respiratory, and peripheral muscle function parameters, and identify parameters indicative of evolving cardiovascular risk (CVR) in COPD patients, using multivariate analysis.
Reduced lung function is a major risk factor for cardiovascular mortality (CV), regardless of age, sex and history of smoking. Similarly, CV events are known causes of mortality in patients with chronic obstructive pulmonary disease (COPD). The investigators propose to determine the parameters influencing the evolution of CV risk in a cohort of COPD patients followed over 5 years. For this the investigators will study the role of inflammation, oxidative stress, and vascular, respiratory and peripheral muscle function parameters. In order to study a sufficient number of patients the investigators propose to group data from two cohorts: a first cohort of 121 COPD patients that already exists (currently closed to inclusions but still undergoing follow-up (NCT00404430)) and a new cohort of 150, decompensated or not, COPD patients. This study is of major scientific interest and will enable to obtain extremely important information to better understand COPD.
Study Type
OBSERVATIONAL
Enrollment
150
University Grenoble Hospital
Grenoble, La Tronche, France
RECRUITINGChange of the pulse wave velocity (PWV)
Measurement of pulse wave velocity (PWV), which reflects cardiovascular risk (CVR). This measure will be performed at each visit (V1, V1 bis, V2, V3, V4, V5 and V6).
Time frame: During 5 years since inclusion (once a year)
Monitoring of COPD exacerbations compared to evolution of PWV
Determination of the relationship between exacerbations and the evolution of the PWV.
Time frame: During 5 years since inclusion
Relationship between the new cardiovascular (CV) events and the evolution of the PWV.
Follow-up of exacerbations compared to new CV events (including myocardial infarction with or without ST segment elevation, ischemic stroke, unexplained sudden death at 5 years).
Time frame: During 5 years since inclusion (once a year)
Correlations between the parameters of severity of pulmonary disease and physical activity.
Measurement of extent of pulmonary disease; exploration of peripheral muscle function; measurement of physical activity; measurements of endothelial function; measurement of cardiac function.
Time frame: During 5 years since inclusion (once a year)
Prevalence of nocturnal "non-dipping" of blood pressure during COPD.
Measurement of ambulatory arterial blood pressure during 24 hours
Time frame: During 5 years since inclusion (once a year)
Impact of sleep disorders and sleep apnea syndrome on the evolution of CVR during COPD.
Measurement of sleep disorders and Sleep Apnea Syndrome
Time frame: At inclusion visit
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