Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?

Ain Shams University30 enrolled

Overview

Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants. We aimed at investigating the current DNA damage in the sperms of adult patients with beta thalassemia major and the effect generated by giving antioxidant treatment for 6 months.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Endocrine Disease Fertility Decreased Male DNA Damage

Interventions

L-Carnitine and N-acetyl cysteineDRUG

Eligibility

Sex: MALEMin age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pubertal patients with beta thalassemia major Exclusion Criteria: * Associated endcrinopathy

Locations (3)

Ain Shams University Hospitals

Cairo Governorate, Cairo Governorate, Egypt

Ain Shams University

Cairo, Egypt

Ain Shams University

Cairo Governorate, Egypt

Outcomes

Primary Outcomes

DNA fragmentation index

Time frame: 6 months

Data from ClinicalTrials.gov

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