Comparing the Diagnostic Role of PET/MRI and of PET/CT Among Patients With Gastric Cancer

Chinese PLA General Hospital100 enrolled

Overview

The results of PET/MRI and PET/CT in each recruited gastric cancer patients will be compared.

A prospective comparison of PET/MRI and PET/CT for gastric cancer will be performed,to evaluate the value of PET/MRI in predicting the preoperative staging and resectability of gastric cancer and investigate the role of PET/MRI in gastric cancer diagnosis.The evaluation parameters are the diagnostic accuracy of gastric cancer staging( including the overall accuracy, sensitivity, and specificity) and the receiver operating characteristic (ROC).

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Gastric Cancer Stage

Interventions

PET/MRIDEVICE

The recruited patients will receive a PET/MRI examination to evaluation the stage and resectability of the cancer.

PET/CTDEVICE

At the next day of PET/MRI examination,A PET/CT examination will be performed.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Histological diagnosis of gastric cancer 2. No previous treatment history for gastric cancer 3. Without complications of obstruction,bleeding and so on 4. Without severe diabetes,the levels of blood glucose \<6.2 mmol/L . 5. No cardiac pacemarker,never stimulator or other metal substitute materials in vivo. Exclusion Criteria: 1. With other neoplastic disease. 2. Suffering acute inflammatory disease 3. History of chemo-radiotherapy 4. Suffering prostate hyperplasia,glaucoma

Outcomes

Primary Outcomes

The results of the PET/MRI and PET/CT examination

Two experienced radiologists independently assess the TNM staging of gastric cancer using preoperative PET/MRI and PET/CT images

Time frame: 3 days

Secondary Outcomes

Histopathological diagnosis

including definitely T stage in Tx, number of regional lymph node metastasis,result of histologic subtypes of carcinoma,result of other cytological examination.

Time frame: 5 days

Results of CT/Endoscopic ultrasound(EUS) image

Experienced radiologists assess definitely T stage in Tx, number of regional lymph node metastasis,with or without distant metastasis.

Time frame: 3 days

Numerical values of Standard uptake value(SUV)

Standard uptake value(SUV) is defined as the ratio of the image derived radioactivity concentration and the whole body concentration of the injected radioactivity.

Time frame: 3 days

Apparent Diffusion Coefficient(ADC)

Apparent Diffusion Coefficient(ADC) will be measured using a curved Placement of region of interest(ROI) to include the high signal and be read out on ADC maps by Diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) analysis software.

Time frame: 3 days

The expression level of Receptor tyrosine-protein kinase erbB-2(HER2)

Acquire from pathology results

Time frame: 5 days

The expression level of Receptors for vascular endothelial growth factor(VEGFR)

Acquire from pathology results

Central Contacts

Lin Chen, Master

CONTACT

86-13801290395 chenlinbj@sina.com

Data from ClinicalTrials.gov

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